[Study the effect of buspirone and trazodone on hematological damage induced by long-term exposure to noise in mice]
Arab Journal of Pharmaceutical Sciences. 2012; 4 (8): 83-90
em Árabe
| IMEMR
| ID: emr-163729
ABSTRACT
The study investigated the effect of stress induced by long-term exposure to noise on body immunity through total white blood cell and lymphatic cell count, and on neutrophil-to-lymphatic cell ratio as a physiological marker of noise-induced stress in rats. In addition, the effect of both buspirone and trazodone in alleviating this negative outcome induced by noise was also investigated on 32 rats aged 90-100 days at the beginning of the study period. Results of the study was consistent with previous theories that noise may be considered as a causative agent which influences body's immune system when it reduces both total white blood cell and lymphatic cell count. Results also showed that the ration of neutrophil-to-lymphatic cell was increased as a result of long-term exposure to noise. Furthermore, the study presented a new evidence of antagonizing and therapeutic effect of buspirone and trazodone to stress-induced physiological damage
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Trazodona
/
Buspirona
/
Hematologia
/
Imunidade
/
Camundongos
/
Neutrófilos
Limite:
Animais
Idioma:
Árabe
Revista:
Arab J. Pharm. Sci.
Ano de publicação:
2012
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