[Plasma homocysteine levels in cataract patients with and without pseudoexfoliation syndrome]

ABSTRACT

To compare total plasma homocysteine [tHcy] levels in cataract patients with and without pseudoexfoliation syndrome [PXS]. In this case-control study 29 [15 female and 14 male] cataract patients with PXS and 29 [16 female and 13 male] cataract patients without PXS were enrolled. Fasting tHcy level was measured using high-performance liquid chromatography and compared between the two groups. Mean age was 68.9 +/- 13.9 years in the PXS group and 63.1 +/- 12.6 in patients without PXS [P=0.69]. Mean plasma tHcy level was 21.08 +/- 11.72 micromol/l in patients with PXS Vs 13.20 +/- 4.23 micromol/l in patient without PXS [P=0.001]. Hyperhomocysteinemia was seen in 17 cases [56.6%] of PXS vs 4 cases [13.8%] of non-PXS subjects [P=0.001]. This study supports the association of hyperhomocysteinemia with pseudoexfoliation syndrome