Prevalence of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus infections in a Saudi Arabian hospital
Journal of Infection and Public Health. 2015; 8 (4): 364-368
em Inglês
| IMEMR
| ID: emr-165667
ABSTRACT
Panton-Valentine leukocidin [PVL] is a two-component toxin associated with the toxicity and virulence of Staphylococcus aureus. The presence of PVL is well documented in community-acquired methicillin-resistant S. aureus [CA-MRSA] and is observed in methicillin-susceptible S. aureus [MSSA] with variable prevalence. We assessed the prevalence of PVL in a sample of 93 MSSA patients in a healthcare facility in Eastern Saudi Arabia using real-time PCR for lukSF-PV genes. The presence or absence of PVL was correlated with age, gender, hospitalization status, infection site and antibiotic resistance. PVL was detected in 28 [30%] patient samples. PVL was associated with a greater likelihood of resistance to trimethoprim-sulfamethoxazole [a resistance of 39.2% of PVL-positive isolates compared to 6.1% of PVL-negative isolates] [p< 0.0007]. These results suggest a significant prevalence of PVL expression in MSSA strains in the study population and call for monitoring of and surveillance programs for PVL status and the selection of appropriate antibiotic treatments
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Índice:
IMEMR (Mediterrâneo Oriental)
Tipo de estudo:
Estudo de prevalência
Idioma:
Inglês
Revista:
J. Infection Public Health
Ano de publicação:
2015
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