Improving the two types of diabetes mellitus using cinnamon infusion

ABSTRACT

The present work was conducted to study the effect of cinnamon extract as traditional infusion on improving the both of type I and II diabetes mellitus. Fifty male albino rats [Sprague Dawley Strain] divided into four main experimental |roups, the first and second main groups used as a negative control groups, the third main group was subjected to type I diabetes and the fourth for type II]. Type I was induced by using streptozotocin [STZ] at dose of 60mg/kg body weight. Type II was induced by feeding rats high fructose diet [HFD] for 15 days. After one week of [STZ] and two week of [HFD] administration blood glucose was determined and the animals of 250-500 mg/dl glucose levels were considered diabetic rats. Then, the third main group of rats divided into the following subgroups [n=5] for type I diabetes 1[st] subgroup fed basal diet [diabetic control], 2[nd] group fed basal diet + cinnamon infusion [1.5 ml/kg b.w. one time], 3[rd] group fed basal diet + cinnamon infusion [1.5 ml/kg b.w. two times], 4[th] group fed basal diet + cinnamon infusion [1.5 ml/kg b.w. three times]. Concerning type II diabetes, similar scheme was designed. All treatments with cinnamon infusion for10 weeks resulted in highly significant differences in blood glucose, AST and ALT compared with diabetic control for type I diabetes. Concerning type II diabetes, after treatment by cinnamon infusion, the blood glucose, ALT, AST decreased significantly by infusion [1.5 ml/Kg, 10%w/v] for one, two, three times compared with diabetic control. Triglycerides, total cholesterol and LDL-c were decreased due to one, two, three of administration, respectively compared to diabetic control, except HDL-c increased and reached to the control value due to the three times of cinnamon infusion. Regarding Type11 diabetes, a similar trend to type I was found due to cinnamon infusion with a slight variation. The insulin levels increased due to the treatment with cinnamon infusion one, two, three times, respectively for type I diabetes. Meanwhile, it decreased due to the above mentioned treatments for type II diabetes. It could be concluded that cinnamon infusion [10%w/v] about [l00ml/day] may be improved the two types of diabetes