Soy isoflavones supplementation for patients with irritable bowel syndrome: a randomized double blind clinical trial
Middle East Journal of Digestive Diseases. 2015; 7 (3): 170-176
em Inglês
| IMEMR
| ID: emr-166606
ABSTRACT
Irritable bowel syndrome [IBS] is one of the common gastrointestinal disorders with unknown etiology. In experimental models, it is proposed that soy isoflavones may suppress the clinical and psychological symptoms of IBS by alteration of gut barrier tight junctions. We conducted this study to evaluate the effects of soy isoflavones on IBS symptoms and patients' quality of life. In a randomized double blind placebo-controlled clinical trial, 67 patients with IBS were allocated to consume either soy isoflavones capsules or a placebo for 6 weeks. The primary outcome was a significant reduction in symptoms severity score and the secondary outcome was a significant improvement in quality of life. 45 participants completed the study. There was no significant changes in mean differences of symptoms severity score between the two groups; however soy isoflavone supplementation could significantly improve the quality of life scores [p=0.009]. Soy isoflavones supplementation could improve the quality of life in patients with IBS; however it did not suppress the symptoms seventy in 6 weeks. Further research with a longer duration is needed to determine the sustained clinical efficacy. This study was registered at clinicaltrials.gov as NCT02026518
Buscar no Google
Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Qualidade de Vida
/
Método Duplo-Cego
/
Isoflavonas
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Adulto
/
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Middle East J. Dig. Dis.
Ano de publicação:
2015
Similares
MEDLINE
...
LILACS
LIS