Dyslipidemia and psoriasis: a case control study

ABSTRACT

To compare the mean values of lipid profile in psoriatic patients and healthy controls. Case control study. Department of Dermatology, PNS Shifa, Karachi, from November 2012 to April 2013. Patients with psoriasis fulfilling the inclusion and exclusion criteria were selected from Dermatology Outpatient Department [OPD] of PNS Shifa, Karachi. After fasting for 14 hours, 5 ml of venous blood was drawn in sterile syringe and submitted to the Hospital Laboratory for lipid profile, by enzymatic method on Hitachi [Roshe[Registered sign]] using reagents by the same firm. The mean values lipid profile in psoriatic patients versus healthy controls were recorded and compared. A total of 256 patients [128 in each group] were enrolled. Mean lipid profile in both groups revealed cholesterol [mg/dl] value of 203.43 +/- 11.43 in cases and 173.64 +/- 13.65 in controls. Triglyceride [mg/dl] was 178.87 +/- 43.60 and in cases 144.23 +/- 34.01 in controls, HDL-C [mg/dl] was 37.81 +/- 10.78 in cases and 41.41 +/- 9.72 in controls while LDL-C [mg/dl] was 139.52 +/- 13.71 in cases and 109.44 +/- 13.80 in controls. Each parameters had p-value < 0.05 which was significant. Dyslipidemia was found in a high percentage of psoriatic patients than healthy controls. Psoriatic patients require thorough lipid and cardiovascular examinations as they should be considered as individuals with increased risk of cardiovascular diseases