SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique
IJRM-Iranian Journal of Reproductive Medicine. 2015; 13 (4): 215-220
em Inglês
| IMEMR
| ID: emr-166769
ABSTRACT
Sulfatase 1 [SULF1] function is to remove the 6-O-sulphate group from heparan sulfate. This action changes the binding sites of extracellular growth factors. SULF1 expression has been reported to be changed in angiogenesis. We hypothesized that single nucleotide polymorphisms [SNPs] of SULF1 would impact clinicopathologic characteristics. Study of SULF1 gene polymorphism with fetus failure in in vitro fertilization [IVF] technique. We studied one common [minor allele frequency >0.05] regulatory SNP, rs6990375, with polymerase chain reaction and restriction fragment length polymorphism method, in 53 infertile women with fetus failure in IVF technique and 53 women with at least one healthy child as controls. We found that rs6990375 is significantly associated with an early failure in IVF and frequency of G allele is high in women with fetus failure in IVF technique [p<0.001]. These findings suggest that SULF1genetic variations may play a role in IVF technique fetus failure. Further studies with large sample sizes on SULF1 SNPs may be useful in support of this claim:
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IMEMR (Mediterrâneo Oriental)
Assunto principal:
Polimorfismo Genético
/
Polimorfismo de Fragmento de Restrição
/
Fertilização in vitro
/
Estudos de Casos e Controles
/
Reação em Cadeia da Polimerase
/
Polimorfismo de Nucleotídeo Único
/
Feto Abortado
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Iran. J. Reprod. Med.
Ano de publicação:
2015
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