In vivo evaluation and safety profile evaluation of Arctostaphylos uva-ursi [L.] Spreng. extract in rabbits

The aim of our research work was to investigate the effects of low dose of Arctostaphylos uva-ursi [L.] Spreng. on rabbits. Crude extract was administered for 90 days in rabbits and hematology, biochemistry parameters and histopathology changes were analyzed. In result of it gender-based variations were observed in hematological, kidney function, liver function, cardiac enzymes and lipid profile. Urine analysis revealed same results as that of standard and control drug. No significant pathology was observed in heart, stomach, liver and kidney tissues of rabbits, treated with A.uva-ursi in a dose of 25 mg/kg/day. Our results justify the use of A. uva-ursi in medicine for treatment of variable pathologies