Histopathologic changes in liver and kidney of male sprague dawley rats treated with extract of Cardiospermum halicacabum L.

ABSTRACT

In traditional medicine Cardiospermum halicacabum L. [Sapindeaceae] is used against various ailments such as rheumatism, nervous diseases, stiffness of the limbs and snakebite. Leaves are crushed and made into a tea, which aids itchy skin. Salted leaves are used as a poultice on swellings. Young leaves can be cooked and used as vegetables. The leaf juice has been used as a treatment for earache as well. In this study we evaluate acute toxicity [10, 50,100 and 500 mg/kg] and pathologic changes in esophagus, stomach, liver and kidney tissues with a magnifying glass and microscope in a row to mark changes to both morphological and histological in comparison to control with the treatment of ethyl acetate extract [dose of 40mg/kg] in male Sprague Dawley rats. The rats were divided into 4 groups consisting of 3 rats per group for acute toxicity and histopathological change. In conclusion, no lethality was observed in acute toxicity study for 7 days. The treatment of ethyl acetate extracts at 40 mg/kg did not show lethal toxicological changes as observed by histopathological examination in the kidney and liver tissues