[ efficacy of horse collagen[Antema] in hemostasis of bleeding due to dental procedures, pilonidal sinus surgery, hemorrhoidectomy and laminectomy]

ABSTRACT

Hemostasis and control of bleeding are important principles in surgery. Control of bleeding with normal procedures such as cauterization and ligation is sometimes hard and even impossible. Considering different effects of collagen including hemostasis acceleration, complete absorption, tissue repair, and flexibility and appropriate traction, it can help maintain hemostasis. In a randomized controlled clinical trial, 92 cases and 91 controls were compared. Horse collagen [Antema] was used in cases while routine procedures were implemented in controls. Patients were evaluated in 4 groups involving dental procedures, pilonidal sinus open surgery, hemorrhoidectomy, and laminectomy. Statistical indices such as mean, standard error, and statistical tests such as t-test and chi-square were used in the analysis. Mean age was 29.48 +/- 1.29 in the cases and 33.2 + 1.5 in the control group. Seventy four [36 cases, 38 controls] undergoing dental procedures, 61[31 cases, 30 controls] pilonidal sinus open surgeries, 31[18 cases, 18 controls] hemorrhoidectomies, and 12[7 cases, 5 control] laminectomies were investigated. Despite higher severity of bleeding in cases [p=0.011, r=0.247], the time of bleeding control [p<0.001] and the time of complete hemostasis[p<0.001] were lower in cases than in the control group. Antema is effective in hemostasis and it may be used as an adjunct material in hemostasis