Pharmacodynamics studies on ricobendazole in male rats

ABSTRACT

The present study was conducted to study the effect of ricobendazole on male fertility, as well as its effects on the liver and kidney functions tests, some hematological parameters and histopathological changes. Forty-five mature male albino rats were used and divided into 3 equal groups. The first group was kept as control and subcutaneously injected with proplyene glycol [2 ml /kg b.wt.]. The second group was received a single subcutaneous injection of ricobendazole at a dose of 7.5 mg/kg bwt. The third group was subcutaneously injected with 7.5 mg / kg bwt twice within 3 weeks interval. The obtained results showed that administration of ricobendazole as single or repeated dose induced a variety of side effects on male reproduction as reduction of testes, epididymis, and accessory sex organs weights and change in sperm characters; decease of sperm count and motility, and increase in sperm abnormalities. liver functions test values such as Serum alanine aminotransferase [ALT] and aspartate aminotransferase [AST] and alkaline phosphatase [AlP] were significantly increased. Moreover, administration of ricobendazole induced histopathological alterations in reproductive organs, liver and kidney. The adverse effects of ricobendazole was more pronounced in repeated dose group. Therefore, caution is required when using repeated doses of ricobendazole