Comparative study on the effect of C667T and A1298C polymorphism in preeclampsic cases

ABSTRACT

To identify polymorphism of methylenetetrahydrofolate reductase gene in women suffering from preeclampsia. From 142 pregnant women we identify 92 women suffer from preeclampsia and 50 healthy controls with normal pregnancy matched for age and socioeconomic status, preeclampsic patient classified as mild preeclampsia 42[45.7%] and severe preeclampsia 50[54.3%]. Blood samples were tested for DNA polymorphism affecting thrombophilia methylenetetrahydrofolate reductase C677T and A1298C. Homozygous TT genotype, T allele of C677T polymorphism has a significantly higher frequency among preeclampsic cases compared to healthy controls [OR=21.7, 1.46, respectively]. Thus TT genotype and T allele may be considered as genetic risk factors for preeclampsic cases. On the other hand, non significant association in either genotype among preeclampsic cases compared to controls regarding to A1298C