Biochemical alterations in the levels of DNA, RNA and protein in discrete areas of rat brain following nuvacron toxicity

ABSTRACT

The levels of DNA, RNA and Protein were estimated in cerebral hemisphere, cerebellum and brain stem of male albino rats with Nuvacron [0, 0, dimethyl - 0 -1 methyl 3 - methylamino - 3 - oxe -1 - propenyl phosphate] 4 mg/kg body weight intraperitoneally [i.p.] daily for 10 days. The daily i.p. dose of Nuvacron depleted the level of DNA and protein in all brain regions. Increased level of RNA was observed in cerebral hemisphere, cerebellum and brain stem