Comparison of oxidative stress content during on-pump and off-pump coronary artery bypass surgery

ABSTRACT

In contrast to conventional on-pump coronary artery bypass grafting [CABG] surgery only mild increase of parameters of oxidative stress is reported during and after off-pump coronary artery bypass grafting. In this study, we attempted to determine the role of off-pump CABG in the myocardial and systemic inflammatory responses. One hundred patients who underwent elective CABG were divided to three groups I] patients underwent off- pump CABG or 2] on-pump CABG surgery with controlled reperfusion and 3] on-pump CABG with noncontrolled reperfusion. We took patients systemic venous blood samples for the measurement of serum level malondialde hyde [MDA], Troponin [cTnI] and total antioxidant [TAC] and blood level superoxiddismotas [SOD], before and after Ischemia and reperfusion. Mean values of decrease left ventricular ejection fraction [LVEF] after surgery in patients group 3 were higher than patients group2 and also [LVEF] in patients group2 were higher than patients group l [PSerum concentration of MDA in the patient's group3were significantly higher than other two groups [P < 0.0001]. The decrease SOD, TAC levels in patient's patient's group3 were more than patient's patient's group2 and then patients group 1. We conclude that oxidative stress biomarker were increase in on-pump CABG. Controlled reperfusion on-pump CABG in comparison with noncontroled reperfusion on-pump CABG reduces oxidative stress. We conclude that off-pump CABG technique appears to reduce oxidative stress