effect of acute normovlumic hemodilution in reducing allogenic red blood cell transfusion during and after cardiac surgery

ABSTRACT

In this study, effect of acute normovlumic hemodilution [ANH] to reduce consumption rate of allogenic blood transfusion was compared with the traditional protocol during and after cardiac surgery. One thousand patients who underwent elective cardiac surgery [CABG, valve surgery were entered into study. In ANH group [n=500/ blood obtained from patients by using a new formula and re-transfused the collected blood at the end of operation. Total amount of a2logenzc packed red blood cell [PRBC] and fresh frozen plasma PFP] transfusion in ANH group was compared with 500patients that had been operated one year ago in our hospital [Historical Control]. Considering the patients baseline hematocrit values A M technique was used in 59% of patients in ANH group, and 12% in control group. In ANH group fewer patients during operation transfused with PRBC and FFP than control group [23.2% vs. 71.4%; p = 0.001 and 3 1.2% vs 77.4%; p = 0.008, respectively. Significantly lower mean PRBCs units transfused in ANH group comparing with control group [1.1 +/- 0.5 vs. 2.4 +/- 1.3 units; p = 0.006]. After surgery PRBCs and FFP transfusion were lower in ANH group than control group. Mean postoperative bleeding was not significantly different in the two groups [884 +/- 304 ml vs 790 +/- 291 ml; p = 0.312]. The incidence of postoperative complications, ICU stay and in-hospital mortality between the two groups were not significantly different [p > 0.05]. In this stu4, using the A M significantly reduce consumption of allogeneic red blood cell and FFP in cardiac surgery patients