Histological changes of some organs in the offspring of mice due to mother malnutrition

ABSTRACT

This work aimed to evaluate the effect of low carbohydrate diet during pregnancy and lactation on the histological pictures of some organs in the offsprings. The animals were classified into two groups The first one was kept as a control group; the second group was fed with a 30% low carbohydrate diet from the mating with male to 21 day after delivery. The specimens were examined histologically. The skin of fetuses fed maternally with low carbohydrate diet showed on aggregration of granules in stratum granulosum that became discontinuous, and a decrease in the epidermal thickness. Kidneys of fetuses fed maternally with low carbohydrate diet showed patchy areas of vacuolar degeneration in the tubular epithelium that became accompanied with hemorrhage later on. Pancreatic tissue from fetuses fed maternally with low carbohydrate diet showed lack of basal basophilia of acinar cells and increase in size of islets of Langerhans. It is concluded that getting a balanced diet by pregnant and lactating mother is very important as our work revealed a great effect of the decrease of carbohydrates on the development of some important organs, which may have a relation to some diseases in the adulthood