Serum level of resistin in patients with hyperthyroidism and hypothyroidism

ABSTRACT

Resistin hormone is a polypeptide hormone belonging to the family of hormone-like resistin molecules. Controversial results have been reported between serum level of resistin and thyroid abnormalities, including hypothyroidism and hyperthyroidism. The purpose of this study was to evaluate the serum level of resistin hormone in patients with hypothyroidism and hyperthyroidism and its association with weight and body mass index. In this case-control cross sectional study 48 patients with hypothyroidism, 34 patients with hyperthyroidism, and 82 individuals as control group were considered. BMI, fasting resistin, TSH, and T4 serum levels were measured by enzyme immunoassay methods. Data were compared using t-test, Pearson correlation coefficient, and ANOVA to evaluate correlation between variables. p< 0.05 was considered statistically significant. Resistin serum levels in hypothyroidism and hyperthyroidism patients was significantly higher than the control group. There was not any significant correlation between resistin serum levels, BMI, age, and thyroid hormones level. Also in hypothyroidism patients a positive correlation was observed between BMI and TSH level, and a negative correlation between BMI and T4 level. The result of this study showed the increase in serum level of resistin in patients with thyroid dysfunction. This correlation was independent of BMI changes in patient. The findings suggest that changing in serum level of resistin may be considered as a criterion for diagnosis of thyroid dysfunction. Although, this hypothesis needs to be more study