Esthesioneuroblastoma

ABSTRACT

To review all cases of esthesioneuroblastoma in Qaem Hospital from 1990 to 2004 with respect to Clinical findings image studies, staging, grading, histopathological and prognostication. Possible cases of esthesioneuroblastoma were retrieved from Neurosurgery, Otorhinolaryngology And Pathology departments. Patients were included on the basis of review of their files or pathology reports. Thirteen possible cases were retrieved. One case was excluded because of no documented pathology. Esthesioneuroblastoma is a malignant neuroendocrine tumor originating in the olfactory mucosa. It is a small blue cell neoplasm with a characteristic lobular architecture. The tumours were staged according to Kadish staging system and Kaplan-Meier survival analysis was used to identify prognostic factors. The Kadish staging system was able to group the patients into prognostically relevant groups. Intracranial involvement and metastases at the time of diagnosis were found to be poor prognostic factors