Correlation between glycosylated hemoglobin and platelet activity among patients with type 2 diabetes mellitus

To determine the correlation between glycosylated hemoglobin level and platelet activity among patients with type 2 diabestes mellitus [T2DM]. This study was conducted in the Department of Medicine, Khyber Teaching Hospital, Peshawar from January to June 2012. Through a Comparative Cross Sectional Study Design, a total of 80 patients with T2DM were selected from Medical Wards and OPDs and were grouped into those with glycated hemoglobin [HbA1c] levels < 7% [Group A, n=33] and those with HbA1c >/= 7% [Group B, n=47 patients]. Both the groups were compared with regards to MPV and HbA1c. The mean age of patients was 47.41 +/- 6.74 years. In group A there were 45.5% [15] males and 54.5% [18] females. In group B there were 48.9% [23] males and 51.1% [24] female patients. MPV was significantly higher in group B as compared to group A [9.21 +/- 0.76 fl vs. 8.29 +/- 0.46 fl; P < 0.001]. Among the group B patients, a positive statistical Pearson's correlation was seen between MPV and HbA1c levels [r = 0.589; p < 0.001]. However, no statistical correlation was seen between MPV and the duration of DM and BMI. There is a significant association between poor glycemic control and increased platelet activity in patients with uncontrolled T2DM