Correlation between serum levels of triiodothyronine [T[3]] and thyroxin [T[4]] and severity of clinical manifestations of uncontrolled thyrotoxicosis

ABSTRACT

The present study was carried out on 30 patients with uncontrolled thyrotoxicosis. Twenty seven patients [90%] were female and three [10%] were male. Their ages ranged between 17 and 56 years with a mean age of 36.6 years. Results revealed a significant correlation between the mean serum level of total triiodothyronine [TT3] and some, but not all, symptoms and signs of thyrotoxicosis. No significant correlation was found with respect to total thyroxin [TT4] level. A significant direct positive correlation was found between Wayne's score and the serum levels TT3 and TT4 [p<0,05]. An inverse relationship existed between serum levels of thyroid stimulating hormone [TSH] and those of TT3 and TT4 [p<0.05]. Fine needle aspiration cytology [FNAC] was not conclusive in pre-operative diagnosis of the disease as compared to post-operative paraffin section biopsies