genetic epidemiological study of congenital malformations at birth in Sharkyia, Egypt

ABSTRACT

A total of 1500 consecutive neonates delivered in Zagazig University Hospitals were subjected to full clinical and genetic evaluation. Social data including parental consanguinity and social class were taken. The prevalence of congenital in malformations [CMs] in the 1500 hospital live births and still births were 3.2%. The malformed neonates [48] were classified into 13 groups according to world Health Organization classification of CMs. The most common anomalies were central nervous system [29.1%], followed by musculoskeletal system [18.9%] and genetic syndromes [10.5%]. Parental consanguinity was found in [54.2%] of malformed cases, indicating the deleterious effects of consanguinity. Our study concludes that overall the inheritance rather than socio-environmental factors contributes significantly in the etiology of different congenital malformations. We further suggest that the basic information of this research might be useful foundation data in future analytic studies on CMs in Egypt