effects of diabetes oncatecholamine neurotransmitter mediating enzymedopamine-beta-hydroxylase and other biochemicalparameters in human serum

ABSTRACT

In Bangladesh weather, environment and pattern of life style are significantly different from those of other developed as well as developing countries. So this makes us curious to determine the serum Dopamine-p-Hydroxylase [DBH] activity, its cofactors and other biochemical parameters in Bangladeshi diabetic patients at different ages of both sexes to determine their changes with age. The study was done in six different age groups of both sexes namely Group I 10-15 years, Group II 15-25 years, Group III 25-35 years, Group IV 35-45 years, Group V 45-55 years and Group VI 55+ years. DBH activity was increased in Groups I, II and decreased in Group VI of both sexes. DBH activity was variable in all other groups. One of the cofactors, ascorbic acid was slightly decreased in all groups. Another cofactor copper was variable. Among the parameters of lipid profiles, only the triacylglycerol level increased in all groups. Other biochemical parameters were variable. From our studies, we concluded that diabetes affects the DBH activity, its cofactors and other biochemical parameters