Fatal sulfasalazine-induced eosinophilic myocarditis in a patient with periodic fever syndrome
Medical Principles and Practice. 2015; 24 (2): 195-197
em Inglês
| IMEMR
| ID: emr-171512
ABSTRACT
The aim of this paper is to report the first case of drug-induced eosinophilic myocarditis [EM] in a patient with hereditary periodic fever syndrome [PFS]. Case A 28-year-old man with hyper-IgD syndrome, one of the PFS, developed a sulfasalazine-induced systemic hypersensitivity reaction complicated by EM. Thirteen days after sulfasalazine introduction, which had been given for arthritis, the patient developed fever, facial/neck edema, rash and cardiogenic shock, and died within 8 h. The autopsy revealed hemophagocytosis, while acute heart failure caused by necrotizing EM was established as the cause of death. This was a case of drug-induced EM in a patient with PFS that had an atypical presentation, rapid evolution and poor outcome:
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Sulfassalazina
/
Eosinofilia
/
Deficiência de Mevalonato Quinase
/
Doenças Hereditárias Autoinflamatórias
/
Síndrome de Hipersensibilidade a Medicamentos
Tipo de estudo:
Relato de Casos
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Med. Princ. Pract.
Ano de publicação:
2015
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