Effect of different polymers on the physico-chemical properties and stability of formulated chloramphenicol eye drops

ABSTRACT

The influence of different polymeric solutions as vehicles on the physical properties and stability of chloramphenicol were studied. Aqueous solution of polyvinylpyrrolidone, methyl cellulose and polyethy lene glycols were used as vehicles. The preparations showed good and stable characteristics for drug content, pH, viscosity and color changes. The theoretical analysis of the obtained results indicated that the drug is stable on storage at different temperatures