Serum B-hCG concentration changes following intramuscular HCG administration

ABSTRACT

In circumstances such as in vitro fertilization [IVF] or in patients with luteal phase defect, one needs to ensure the establishment of pregnancy as soon as possible. At the same time, a question arises How can a physician make sure that the Beta-hCG is of an endogenous source and not the residue of the prescribed drugs [hCG]? In this article we have studied the elimination time of IM injection of 5000 IU hCG in 11 normal, and IM injection of 5000 and 10,000 IU hCG in 11 Rokitansky patients. The time of complete elimination of Beta-hCG from the circulation in 10 normal women and 5 Rokitansky patients receiving 5000 IU of hCG were 7-11, and 7-8 days respectively. There was no statistically significant difference between these two groups. Comparing the two groups of Rokitansky patients receiving 5,000 and 10,000 IU of hCG, the elimination time were dose-dependent, and were significantly different from each other [P<0.01]. We conclude that when the serum level of Beta-hCG is higher than 5m lU/mi after 11 and 14 days with 5,000 and 10,000 IU of hCG injection, it could be accepted as an implanted pregnancy