Association between serum paraoxonase 1 activities [PONase/AREase] and L55M polymorphism in risk of female infertility
AJMB-Avicenna Journal of Medical Biotechnology. 2015; 7 (4): 173-178
em Inglês
| IMEMR
| ID: emr-173154
ABSTRACT
The risk of developing female infertility has been associated with gene polymorphisms that decrease the activity of enzymes involved in systemic Oxidative Stress [OS]. In this study, PON1 L55M polymorphism for association with susceptibility to infertility was investigated among Iranian female population. Samples from 120 Iranian females [20 endometriosis; 30 Polycystic Ovary Syndrome [PCO]; 70 controls] were analyzed and PCR-RFLP assay was used to determine the PON1 rs854560 [L55M] frequencies. The paraoxonase [PONase] and arilesterase [AREase] activities of PON1 enzyme were also assessed in order to investigate the association between serum PON1 activities, female infertility, and PON1 L55M polymorphism. The women with a MM genotype [p=0.021; OR=2.55] showed more possibilities of experiencing infertility than those with a LM genotype [p=0.039; OR=1.91]. According to LSD test, endometriosis subjects had significantly lower paraoxonase enzyme activity compared to control group [p=0.0024; CI=95%]. No significant difference was found in women with PCOS for both PONase and AREase activity in comparison with control group [p=0.469; CI=95%]. Furthermore, PON1 activities were the highest in LL genotype followed by LM and then MM genotype [MM
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Índice:
IMEMR (Mediterrâneo Oriental)
Idioma:
Inglês
Revista:
Avicenna J. Med. Biotechnol.
Ano de publicação:
2015
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