Impairment of immune response by meprobamate

ABSTRACT

Previous studies from this laboratory and others showed that perturbations of the central nervous system modulate immune function. This study investigates the effects of meprobamate on the immune response. It leads to low humoral response shown by decreased precipitin titers, and elevated cellular immune response shown by the increased level of B-glucuronidase in both serum and Kupffer cells. However, the response returns to normal levels by the treatment with thiola. These data further substantiate the existence of a link between the brain and the immune response