Effect of platelet-rich plasma intra articular injection on patients with primary knee osteoarthritis

ABSTRACT

Background: Osteoarthritis [OA] is the most common type of arthritis. It is a degenerative joint disease. OA is usually defined according to radiographic changes. Conventional radiographs [CR] were considered the most relevant outcome measure to assess the progression of OA in clinical trials and epidemiological studies. Many modalities are used in treatment of knee OA. There is a distinct need for new procedures that are cost effective by reducing the need for pharmaceutical and surgical management, while targeting the biochemical process of OA. Platelet-rich plasma [PRP] is one of these new procedures. PRP was found to increase hyaluronic acid [HA] concentration, stabilizing angiogenesis in patients with osteoarthritic knees