Preventive effects of sesame seeds on hyperglycemia and serum lipids in fructose fed mice

ABSTRACT

The aim of the study was to determine the effects of sesame seeds on anthropometric measurements [height, weight and body mass index], blood glucose, lipid profile and liver function tests In high fructose diet [HFD] fed mice. Arandomized experimental laboratory trial. The study was conducted at National Institute of Health Sciences, Islamabad from 1[st] February 2013 till 31st January 2014. We allocated 30 female Balb/c mice into three groups. Control Group I [n=10] mice who were fed with standard laboratory diet were compared with Experimental groups; Group Ha [n=10] mice were fed on high fructose diet [HFD] for 08 weeks, Group Mb [n=10] mice were fed with HFD plus sesame meal for 08 weeks. Anthropometric measurements [Weight, Height and BMI] and serum lipid profile, liver function tests and blood glucose were measured at baseline and after 8 weeks. The mean weight of the Balb/c mice was 23.33 +/- 1.44 grams, the mean height was 8.4510.314 cm and the mean BMI was 3.27 +/- 0.33. The anthropometric measurement of the three groups of mice was similar at the baseline. After 8 weeks there was significant weight gain in the HFD group [Ma] 35.914.5 and HFD plus Sesame diet group [lib] 3014.5 as compared to control group 29.112.84. However the weight gain in HFD plus Sesame diet group [Mb] was significantly lesser as compared to the HFD alone group, signifying that perhaps sesame seeds prevented the significant weight. The mice that were fed on HFD [Ma] had significant derangement of their liver function tests, lipid profile and blood glucose as compared to control and HFD plus Sesame diet group [Mb]. High fructose diet results in significant weight gain, elevation of liver function tests, derangement of lipid profile and hyperglycemia. Sesame diet was effective in preventing these anthropometric and biochemical derangements. Hence it is likely that sesame diet has a hepato-protective role which needs to be confirmed by studies on a larger scale to demonstrate this hepatoprotective effect of sesame seeds beyond doubt