Fibroblast growth factor-2 enhanced the recruitment of progenitor cells and myelin repair in experimental Demyelination of rat Hippocampal formations

ABSTRACT

Objective: Hippocampal insults have been observed in multiple sclerosis [MS] patients. Fibroblast growth factor-2 [FGF2] induces neurogenesis in the hippocampus and enhances the proliferation, migration and differentiation of oligodendrocyte progenitor cells [OPCs]. In the current study, we have investigated the effect of FGF2 on the processes of gliotoxin induced demyelination and subsequent remyelination in the hippocampus