No relationship between most polymorphisms of steroidogenic acute regulatory [StAR] gene with polycystic ovarian syndrome

ABSTRACT

Background: Polycystic ovary syndrome [PCOS] is one of the most common endocrine women's disorders in reproductive age. Hyperandrogenism has a critical role in the etiology of PCOS and it can cause fault in Steroidogenesis process. During steroidogenesis, steroidogenic acute regulatory protein [StAR] seems to increase the delivery of cholesterol through mitochondrial membrane. Therefore, polymorphisms of StAR might effect on this protein and play a role in the etiology of PCOS