Journal of the Egyptian Society of Parasitology. 2015; 45 (3): 559-570
em Inglês
| IMEMR
| ID: emr-175053
ABSTRACT
Cryptosporidisis parvum is a zoonotic protozoan parasite infects intestinal epithelial cells causing a major health problem for man and animals. Experimentally the immunologic mediated elimination of C. parvum requires CD4+ T cells and IFN-Gamma. But, the innate immune responses also have a significant protective role in both man and animals. the mucosal immune response to C. parvum in C57BL/6 neonatal and GKO mice shows a concomitant Th1 and Th2 cytokine mRNA expression, with a crucial role for IFN-Gamma in the resolution of the infection.NK cells and IFN-Gamma have been shown to be important components in immunity in T and B cell-deficient mice, but IFN-Gamma-dependent resistance is demonstrated in alymphocytic mice. Epithelial cells may play a vital role in immunity as once infected these cells have increased expression of inflammatory chemokines and cytokines and demonstrate anti-infection killing mechanisms. C. parvum immunological response was used to evaluate the efficacy of anti-cryptospori- disis agents of Garlic, Ginger, Mirazid and Metronidazole in experimentally infected mice
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Plantas Medicinais
/
Resinas Vegetais
/
Cryptosporidium parvum
/
Zingiber officinale
/
Alho
/
Fitoterapia
/
Metronidazol
Limite:
Animais
Idioma:
Inglês
Revista:
J. Egypt. Soc. Parasitol.
Ano de publicação:
2015
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