Novel tetrahydronaphthyl thiazole derivatives of anticipated anticancer activity

ABSTRACT

A new series of some new N-arylidene-4-[1,2,3,4-tetrahydr onaphthalene-6-yl]thiazol-2-amine Schiff bases Il cyclized either by thioglycolic acid or thiosalicylic acid afforded thiazolidinone and benzothiazine derivatives III and IV, respectively. Also, amine I condensed with alpha-halocarbonyl compounds to give the corresponding amino derivatives V. Cyclocondcnsation of the chloroacetamido derivative Vd gave the pyrazine, quinoxaline, benzoxazine and chlorobenzoxazine derivatives VI-VIIIb, respectively. Compounds IIc, III, Vb, VI are evaluated as anticancer agents in human liver carcinoma cell line [HePG2] and breast carcinoma cell line [MCF7] and showed promising activities against these two cell lines