Alcohol dehydrogenase genotype [ADH2 and ADH3] in alcoholism of Iraqi people

ABSTRACT

Objective: The polymorphic human liver enzyme alcohol dehydrogenase [ADH] is responsible for the oxidative metabolism of ethanol. An allele encoding active form of cytosolic enzyme is known to reduce the likelihood of alcoholism in Iraqi men. The polymorphisms of ADH modifies the predisposition to the development of alcoholism. Determination of genotypes ADH2 and ADH3 loci in alcoholic and nonalcoholic Iraqi men