study of DNA methyltransferase-3B promoter variant genotype among Iranian sporadic breast cancer patients

ABSTRACT

Background: DNA methyltransferase-3B [DNMT3B] is an important enzyme responsible for maintaining the DNA methylation pattern in eukaryotic cells. In this study we have investigated the correlation between the 46359C[rightwards arrow]T polymorphism in the DNMT3B gene and the risk of breast cancer incidence among sporadic breast cancer patients in Fars Province, Southern Iran