Synthesis and antibacterial screening of S-substituted derivatives of 5-[3,4-methylenedioxyphenyl]-1,3,4-oxadiazol-2-thiol
Pakistan Journal of Pharmaceutical Sciences. 2016; 29 (1): 27-34
em Inglês
| IMEMR
| ID: emr-177264
ABSTRACT
The most emerging class among the heterocyclic compounds is 1,3,4-oxadiazoles for their diverse biological activities. In the present research work, piperonylic acid [1] was converted consecutively into corresponding ester [2], hydrazide [3] and 1,3,4-oxadiazole [4] through intermolecular cyclization. The synthesized compound 4 was subjected further to S-alkylation/aralkylation, using alkyl/aralkyl halides [5a-m] and S-substituted-1,3,4-oxadiazole derivatives were synthesized [6a-m]. The structure elucidation of the synthesized molecules was processed through [1]H-NMR, IR and mass spectral data. The antibacterial activity showed these molecules moderately good inhibitors of gram-negative and gram-positive bacteria
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Índice:
IMEMR (Mediterrâneo Oriental)
Tipo de estudo:
Estudo de rastreamento
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2016
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