Effect of Cinnamon Bark on Streptozotocin induced Diabetic Male Mice

ABSTRACT

To determine the effect of cinnamon bark on glucose metabolism in streptozotocin induced diabetic mice. Interventional experimental study. This study was carried out in the animal house of National Institute of Health, Islamabad in collaboration with Department of Biochemistry, Islamic International Medical College from 7[th] November 2013 till 21[th] January 2014. Fifty albino Balb/C male mice were included in study. Among them, ten mice were used for cardiac puncture for baseline biochemical analysis. While in rest of the forty mice, Type 2 diabetes was induced by intraperitoneal administration of low dose [40 mg/kg] streptozotocin [streptozotocin] injections for four consecutive days. Diabetes induction was confirmed on day 21. Two groups with twenty mice each were made. Group I was control group that was left untreated while group II received cinnamon bark diet at a dose of 5mg/day for 8 weeks. At baseline the mean BGR was 135.9 +/- 29.67 mg/dl and day 21; BGR of 336.85 +/- 46.4 mg/dl. In the experimental group the mean BGR after 08 weeks of cinnamon therapy was 184.1 +/- 24.56 mg/dl; The BGR significantly decreased after 08 weeks of cinnamon therapy as compared to Day 21 BGR; p=0.00. The mean BGR at 08 weeks was significantly decreased between the control and experimental groups; p= 0.000. At baseline the HbA1c ranged from 5.5 to 6.2% with a mean of 5.93 +/- 0.20. In the Control group after 08 weeks the mean HbA1c was 11.27 +/- 1.28%. While in the experimental group the mean HbA1c after 08 weeks of cinnamon therapy was 7.7 +/- 0.68%. The mean HbA1c at 08 weeks was significantly decreased between the control and experimental groups; p= 0.000. Cinnamon therapy was effective in improving BGR and HbA1c levels in a diabetes type 2 induced male mice