Pharmacological rational of dry ripe fruit of Aegle marmelos L. as an anti-nociceptive agent in different painful conditions

ABSTRACT

The aim of study is to investigate central and peripheral analgesic effects of methanolic extract of dry ripe fruit of Aegle marmelos Linn. Corea [Am. Cr] by two methods, tail flick test and acetic acid induced writhing test at 100, 250 and 500mg/kg doses in animal models. Analgesic activity against tail flick test revealed that Am. Cr induced significant increase in latency period in dose dependent manner i.e. 65.38% at 100mg/kg, 395.37% at 250mg/kg [p<0.01] and 459.25% at 500mg/kg [p<0.01] body weight at 1hr after drug delivery while at 2hr effect decreased i.e. 61.53% at 100mg/kg, 161.11% [p<0.01] at 250mg/kg and 165.74% [p<0.01] at 500mg/kg but interestingly again there is an elongation in latency period at 3hr i.e. 106.15% at 100mg/kg dose, 251.85% [p<0.01] at 250mg/kg and 293.51% [p<0.05] at 500mg/kg respectively. The standard drug Diclofenac sodium at the dose of 5mg/kg continuously increased the latency period but less significantly as compared to the test substance i.e. 79.43%, 113.08% and 222.42% [p<0.05] respectively. Acetic acid induced writhing test produced highest significant activity at the dose of 100mg/kg i.e. 89.83% [p<0.01] as compared to Diclofenic sodium [standard drug] at a dose of 5mg/kg body weight i.e 63.63% [p<0.01]. It is concluded that dry ripe fruit of A. marmelos possesses significant dual analgesic activities i.e. central and peripheral