Comparative effects of metformin and pioglitazone on lipid profile of rabbits

ABSTRACT

This is the initial part of study in which the effects of two oral hypoglycemic drugs metformin and pioglitazone were studied on lipid profile of rabbits. White rabbits of both sexes were equally divided in to three groups each comprising of seven animals. Control group was given distilled water 2m1/kg, animals of group II were given metformin in the dose of 22mg/kg and animals of group III received pioglitazone in the dose of 0.5mg/kg. Serum concentration of cholesterol, very low-density lipoprotein [VLDL], triglycerides [TGs], low density lipoprotein [LDL] and high density lipoprotein [HDL] were measured after 8 week of oral dosing. Results shows that after 8 weeks animals received metformin did not reveal any significant change in lipid profile, but animals received pioglitazone showed significant [P<0.05] decrease in lipid profile, the decrease in cholesterol, LDL, VLDL and triglycerides is favorable however decrease in HDL is troublesome and warrant further investigations