Clinical evaluation of herbal coded formulation cran-off to urixin in the treatment of urinary tract infection

ABSTRACT

Urinary Tract Infections are the largest group of infections after the respiratory tract infections. In 85% of the cases the causative organism is E. Coli. A clinical trial was conducted to evaluate the efficacy of coded herbal formulation [Cran off] [Test drug] for the treatment of Urinary tract infection comparing with Urixin [Control]. One hundred and thirty patients suffering from Urinary tract infection from both groups [Males 45, mean age 34+/-14 and females 85, mean age 33+/-13 year, range 15-55] were enrolled in the trial and divided in to two groups according to treatment regimens. Cran off [Test drug] 500mg two capsules and Urixin [Pipemidic Acid Trihydrate JP15] [Control] 400mg capsules twice daily were prescribed for 2-3 weeks. Urinary tract infection was improved in 23 [35.38%] patients out of 65 patients by the use of Cran off [Test drug], and in 15 [23.07%] patients out of 65 by the use of Urixin [Control drug]. Furthermore, there was a significant improvement in Urinary tract infection associated clinical features as compared to Urixin. It is concluded that Cran off possesses a therapeutic value for the improvement of urinary tract infection and its associated symptoms as compared to Urixin