Effect of multiple drug administration on gross toxicities and electrolytes

ABSTRACT

Pakistan being a developing country faces increased burden of cardiovascular disorders and epilepsy along with chronic non-communicable disease such as diabetes mellitus. It is therefore; important to identify; the potential of toxicity that might occur as a result of the drug-drug interaction upon simultaneous use of anti-epileptics with anti-hypertensive, anti-arrhythmic and anti-diabetic. Present study was planned to explore the changes in gross toxicities and electrolytes with individual and multiple administration of anti-epileptic, anti-hypertensive, anti-arrhythmic and anti-diabetic. The study was conducted in normal rabbits of either sex following administration of drugs for a period of 60 days; sodium, potassium and calcium levels were analyzed at the completion of dosing and again after drug-free interval of 15 days, results of the study suggests that animals received amiodarone-glibenclamie-captopril-oxcarbazepine combination showed hypokalemia and hypocalcaemia which remained significant even after drug-free interval, however animal received amiodarone-glibenclamide-verapamil-oxcarbazepine combination showed hypocalcemia at the completion of dosing and hyperkalemia, hypercalcemia after drug-free interval