Lead induced effects on renal alkaline phosphatase with role of zinc in albino rats

ABSTRACT

Kidneys are adversely affected by a wide variety of therapeutic agents and chemicals including the environmental pollutants such as Lead. The nephrotoxic effects of lead have been widely studied. The proximal tubular cells are especially vulnerable to lead induced damage to membrane structure and function, characterized by enzymuria and inhibition of certain renal enzymes. Alkaline phosphatase activity is also known to be suppressed which has been evaluated in the present study by enzyme histochemistry. Moreover Zinc, an essential micronutrient has been used to minimize the effects of lead