Study of gonadal hormones in Egyptian female children with sickle cell anemia in correlation with iron overload: single center study

ABSTRACT

Objective/Background: Sickle cell disease is a hereditary hemoglobinopathy characterized by abnormal hemoglobin production, hemolytic anemia, and intermittent occlusion of small blood vessels, leading to tissue ischemia, chronic organ damage, and organ dysfunction including endocrine organs. The aim of this work was to evaluate some gonadal hormones in female children with sickle cell anemia [SCA] in correlation with iron overload