Synthesis and anti-intracellular Copper overload evaluation of Nanoconjugated D-penicillamine -Dendrimer in Wilson's model cells
Journal of Gorgan University of Medical Sciences. 2016; 18 (1): 114-119
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ABSTRACT
Background and Objective:
Wilson's disease [WD] is caused by mutation to the cooer-transporting gene ATP7B. Chelation therapy is the main protochol of treatment for patients with Wilson's disease. D-penicillamine is one of the well-known chelator agants which is used in WD treatment but it can not enter into the intracellular space.This study was done to evaluate the synthesis and anti-intracellular Copper overload evaluation of Nanoconjugated D-penicillamine -Dendrimer in Wilson's model cells
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Penicilamina
/
Cobre
/
Dendrímeros
Idioma:
Persa
Revista:
J. Gorgan Univ. Med. Sci.
Ano de publicação:
2016
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