Human Neutrophil Elastase induce Interleukin-10 expression in peripheral blood mononuclear cells through protein kinase c theta/delta and phospholipase pathways

ABSTRACT

Objective: Neutrophils have an important role in the rapid innate immune response, and the release or active secretion of elastase from neutrophils is linked to various inflammatory responses. Purpose of this study was to determine how the human neutrophil elastase affects the interleukin-10 [IL-10] response in peripheral blood mononuclear cells [PBMC]