Effect of low frequency electrical stimulation of dentate gyrus on amygdala kindling_acquisition in rats

ABSTRACT

Background: Low frequency stimulation [LFS] has been recently suggested as an antiepileptic method in treating the drugresistant epileptic syndromes such as temporal lobe epilepsy. So far, in the most clinical and experimental studies, LFS has been applied to the seizure focus itself. Considering the role of dentate gyrus in spreading of the limbic seizures, in the present study the effect of LFS of dentate gyrus on amygdala kindling-induced seizures was investigated