Transforming growth factor beta-1 [Arg25Pro] SNPs: genetic and penotypic correlations in psoriatic Egyptian population

ABSTRACT

Associations have been described between polymorphisms of cytokine and growth factor genes and susceptibility to, or progression of, an increasing number of diseases. TGF-beta 1 plays an important role in the pathogenesis of psoriasis. In this study, single nucleotide polymorphisms [SNPs] in the TGF beta1gene were investigated as possible markets for the susceptibility or/and progression of psoriasis. Seventy six Egyptian psoriatic patients and eighty controls were screened for one TGF beta 1 SNPs Arg25Pro. There were insignificant differences between psoriatic patients and controls in allele frequencies of SNP Arg25Pro. However, a significant association between a psoriasis area severity index [PASI] score and the carrying G allele was found [p=0.02], indicating an association with the severity of psoriasis. There was no significant association in carrying any of the alleles between males and females. It is concluded that there is a genetic associations Arg25Pro and the severity of psoriasis. This means that Arg25 may influence clinical course of psoriasis. TGFB1 SNPs may be useful prognostic indiacators for the progression/severity of psoriasis