Antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit

ABSTRACT

The objective of present study was to evaluate the antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit. The parent extract was ethanolic extract while its sub fractions were prepared in n-hexane, chloroform and n-butanol. The method based on scavenging activity and reduction capability of 1, 1-diphenyl-2- picrylhydrazyl radical [DPPH]. N-butanol fraction was the most effective antioxidant with 87.0 +/- 1.15 activity but the activity was less than ascorbic acid i.e. 93.74 +/- 0.12. Highly significant urease inhibition was shown by crude ethanolic extract [71.00 +/- 0.2a] with IC[50] [392.66 +/- 2.1] followed by aqueous fraction [68.00 +/- 0.5e] with IC[50] [159.83 +/- 2.8]. The results of crude ethanolic extract and aqueous extracts were highly significant [p<0.05] than standard Thiourea. Present study showed that Vaccinium macrocarpon exhibits potent antiurease and antioxidant activities