Peptic ulcer disease: pathogenesis and diagnosis

ABSTRACT

Helicobacter pylori is a gram-negative bacteria which forms colonies in gastric mucosa and is responsible for peptic ulcer diseases [PUDs]. The present review deals with the strategies employed in the diagnosis of H. Pylori infection. The diagnostic techniques for H. pylori infection are categorized into invasive and non-invasive. The invasive techniques include endoscopy, histological studies, culture and rapid urease test whereas 13C-urea breath test, stool antigen test, blood test, serology and PCR are included in non-invasive techniques. A brief outline of these techniques with their selection criteria has been discussed in this review