Hypolipidemic polysaccharides from Hyphaene thebaica fruits

ABSTRACT

The effect of oral consumption of polysawharides isolated from Hyphaene thebaica [L.] Mart fruits on lipid profile of female and male Sprague - Dawley hyperlipidemic rats was investigated. The animals were orally treated with isolated pectin in two different doses [130 and 260 mg/ kg.b.w.]. Lipid profile of the treated animals was obtained and compared with the untreated hyperlipidemic ones. This experiment showed decreasing of total cholesterol [TC], triglycerides [TG] and nonhigh density lipoprotein -cholesterol [non HDL-C] in the animals treated with the polysaccharides by 47%, 32% and 72.6% respectively for the 1[st] dose, and by 56%, 44% and 77% respectively for the 2[nd] dose. The percentage of increase in high density lipoprotein [HDL - C] is 24.8% and 47.7% for the 1[st] and 2[nd] dose respectively. It can be concluded that polyiaccharides [pectin] of Hyphaene thebaica produced significant improvements in level of non HDL-C and other lipid parameters when used as monotherapy. The used doses were effectives, but action of the higher dose was more prominent